March Madness 2025: Top Bracket Busters and Betting Upset Picks to Watch

March Madness 2025: Top Bracket Busters and Betting Upset Picks to Watch

By Marcus Sullivan

March 22, 2025 at 07:49 PM

Two basketball players face off court

Two basketball players face off court

With March Madness 2025 upon us, let's explore the most promising bracket-busting opportunities and valuable betting options for the NCAA Tournament's first round.

Most Likely Bracket Upsets

#12 Colorado State over #5 Memphis

  • Only underdog currently favored by oddsmakers
  • Top-3 ranked in Mountain West for both offense and defense
  • Strong matchup against Memphis' playing style

#10 Arkansas over #7 Kansas

  • 6th best scoring defense in SEC
  • Matches up well with Kansas' current roster

#12 UC San Diego over #5 Michigan

  • Impressive 30-4 record
  • #1 in Big West scoring defense
  • #3 in conference scoring

High-Risk, High-Reward Upset Picks

13-Seed: Akron (+750) over Arizona

  • Leading MAC offense (84.6 PPG)
  • Arizona's defense ranks 13th in conference
  • 11.6% implied win probability

14-Seed: Troy (+500) over Kentucky

  • Top-3 Sun Belt defense
  • Kentucky allows 77.9 PPG (SEC second-worst)
  • 16.67% implied win probability

15-Seed: Bryant (+1250) over MSU

  • American East scoring leaders (86.4 PPG)
  • 7.41% implied win probability
  • Strong offensive capability against Big Ten champion

Best First Round Betting Values

New Mexico (+150)

  • Mountain West's top offense (81.2 PPG)
  • 34.7% from three-point range
  • 4th in KenPom tempo rankings
  • Facing slumping Marquette (lost 3 of last 4)

Grand Canyon (+450)

  • WAC offensive powerhouse (79.9 PPG)
  • 18.18% implied win probability
  • Favorable matchup against Maryland's pace

Keep monitoring public betting splits as they become available for additional value opportunities.

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