The South Region of the 2022 NCAA Tournament features three top-five seeds in the Sweet 16, with Michigan looking to play spoiler. Here's a comprehensive breakdown of the matchups and predictions:

Villanova (-5.0) vs. Michigan

• Villanova's efficient offense meets Michigan's inside scoring approach
• Both teams excel defensively
• Prediction: Villanova to cover the spread with superior offensive execution

Arizona (-1.5) vs. Houston

• Contrasting styles: Houston's defense vs. Arizona's high-scoring offense
• Arizona averaging 80 points per game
• Arizona holds athletic advantage
• Prediction: Arizona to win and cover the slim spread

Regional Final Prediction

• Arizona and Villanova projected to advance
• Arizona's explosive offense expected to overwhelm Villanova
• Final Pick: Arizona advances to Final Four as #1 seed wins South Region

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