The Indianapolis Colts (4-7-1) face the Dallas Cowboys (8-3) in a Week 13 Sunday Night Football matchup at AT&T Stadium. The Cowboys enter as 10.5-point favorites.

The Colts are coming off a close loss to the Steelers on Monday Night Football. Their biggest challenge will be protecting quarterback Matt Ryan against Dallas's league-leading pass rush. The Colts will need creative blocking schemes and an effective running game to give Ryan time in the pocket.

The Cowboys' defense dominated their last game against the Giants on Thanksgiving, shutting down Saquon Barkley and pressuring Daniel Jones. Offensively, Dak Prescott has excelled since returning from injury, developing strong chemistry with receivers CeeDee Lamb and Michael Gallup.

Key Factors:

• Colts must establish the run game to reduce pressure on Matt Ryan
• Cowboys' pass rush leads the NFL in sacks
• Dallas needs disciplined defense to avoid potential upset
• Prescott-Lamb connection has been particularly effective recently

For Indianapolis to have a chance, they'll need to disguise their run plays effectively while finding ways to protect Ryan. Dallas simply needs to maintain their defensive discipline and avoid overaggressive mistakes as the heavy favorite.

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