The Cincinnati Bengals enter their season opener against the Pittsburgh Steelers as 6.5-point favorites, riding momentum from winning their last three matchups against their division rivals.

Cincinnati's running game, led by Joe Mixon who rushed for 165 yards and 2 TDs in their last meeting, poses a significant threat to Pittsburgh's rush defense - which had its worst showing since the AFL-NFL merger last season. While the Steelers added Tyson Alualu and Larry Ogunjobi to address these defensive concerns, they'll need to prove they can contain the Bengals' balanced offensive attack.

For Pittsburgh, Mitch Trubisky gets the start over rookie Kenny Pickett as they begin the post-Roethlisberger era. The Steelers' success heavily depends on an unproven offensive line and Trubisky's ability to execute Matt Canada's offense effectively. Key offensive concerns include:

• Najee Harris dealing with a lis franc injury
• Rookie WR Calvin Austin III out with injury
• Questionable offensive line quality

Betting Analysis:

• Spread: Bengals -6.5
• Key Factor: Cincinnati's dominant rushing attack vs Pittsburgh's weak run defense
• Prediction: Bengals to cover as they pull away in second half

The Bengals' balanced offense and recent dominance in this rivalry, combined with Pittsburgh's offensive line concerns and quarterback transition, make Cincinnati the clear favorite to win and cover.

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