Cleveland Guardians vs. Chicago White Sox: Critical AL Central Showdown Betting Preview September 21

Cleveland Guardians vs. Chicago White Sox: Critical AL Central Showdown Betting Preview September 21

By Marcus Sullivan

March 1, 2025 at 10:17 PM

The Cleveland Guardians (81-67) face the Chicago White Sox (76-72) at Guaranteed Rate Field on Wednesday, September 21 at 8:10 p.m. Coming off a wild 10-7 extra-innings victory, the Guardians look to extend their AL Central lead.

Game Details:

  • White Sox are (-127) favorites
  • Guardians at (+112)
  • Run line: Cleveland +1.5 (-193)
  • Over/Under: 7.5 runs

Pitching Matchup:

  • Guardians: Triston McKenzie (10-11, 3.08 ERA, 0.97 WHIP)
  • White Sox: Lance Lynn (7-5, 3.99 ERA, 1.07 WHIP)

Key Stats:

  • McKenzie: 5 ER in last 19.2 innings with 18 strikeouts
  • Lynn: Won 4 straight, allowing just 3 ER in 26.1 innings
  • Jose Ramirez vs Lynn: .345, 4 HR, 8 RBI in 29 at-bats
  • Seby Zavala vs McKenzie: 2 HR, 5 RBI in 6 at-bats

Analysis: The Guardians aim to increase their 5-game division lead with 14 games remaining. While Lynn has been dominant recently, Cleveland's offense showed resilience in Tuesday's win. McKenzie's consistency gives the Guardians a strong chance at securing the series win, though they'll need to overcome Lynn's hot streak.

For Chicago, this is essentially a must-win game to keep their slim playoff hopes alive. The White Sox must bounce back from Tuesday's devastating extra-innings collapse to avoid falling six games behind in the division race.

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