March Madness 2025: Complete First-Round Betting Odds, Spreads and Lines for All NCAA Tournament Games
The 2025 NCAA Tournament first-round matchups are set, with several notable betting lines catching attention. Here's what you need to know about the key games and odds:
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Notable First-Round Betting Lines:
• #12 Colorado State (-3.5) vs #5 Memphis
- Only double-digit seed favored in first round
- Line opened at -2.5, quickly moved to -3.5
- Analytics heavily favor Colorado State (ranked in high 30s vs Memphis in mid-60s)
Biggest Spreads:
• Houston (-27.5) vs SIU Edwardsville
- Largest first-round spread
- Total set at tournament-low 127.5
- KenPom projects 75-51 Houston victory
• Florida (-26.5) vs Norfolk State
- Second-largest spread
- Florida entering on strong run after SEC Tournament title
Totals to Watch:
Highest:
- Akron vs Arizona: 167.5
- Both teams play up-tempo (Akron 16th, Arizona 54th in pace)
- Akron strong over bet (19-12-1 O/U)
Lowest:
- SIU Edwardsville vs Houston: 127.5
- Houston: #1 defense, 5th-slowest pace
- SIUE: #255 offense, below-average pace
Cooper Flagg's cleared ankle injury has reinstated Duke as outright tournament favorites. All odds reflect opening lines and are subject to change.