MLB Best Bets for April 17: Guardians-Orioles Matchup Headlines Thursday's Top Betting Picks

By Marcus Sullivan

April 24, 2025 at 06:13 AM

MLB best bets and predictions for April 17's slate of games featuring three compelling matchups.

Baseball catcher awaits incoming pitch

Baseball catcher awaits incoming pitch

Best Bet #1: Reds First 5 Innings Moneyline (-145) vs Mariners

  • Mariners' Emerson Hancock struggles with 4.75 ERA, 1.34 WHIP in 2024
  • Reds' Brady Singer shows promise with 3.18 ERA, 1.06 WHIP in 2025
  • Mariners' offense underperforming at 3.88 runs per game

Best Bet #2: Guardians vs Orioles First 5 Innings Under 2.5 (+300)

  • Orioles rank bottom half in wOBA (.307) and OBP (.300)
  • Guardians' Tanner Bibee excelling with 10.1 scoreless innings in last two starts
  • Orioles' Tomoyuki Sugano maintains solid 3.86 ERA in MLB debut season

Best Bet #3: Angels vs Rangers Over 9.5 Runs

  • Rangers' Kumar Rocker struggling with 7.94 ERA, 1.94 WHIP
  • Angels' Jack Kochanowicz showing regression with 5.74 ERA
  • Angels rank 12th in runs per game (4.47)
  • Both teams feature potent offenses and vulnerable pitching

Supporting Statistics:

  • Guardians: 22nd in runs scored (3.88 RPG)
  • Mariners: -6 run differential through 18 games
  • Reds: +13 run differential through 18 games
  • Orioles: 7-10 record, ranking 31st in OBP (.300)

These picks consider current team performance, pitcher matchups, and offensive capabilities, providing value opportunities for MLB bettors.

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