MLB Best Bets for April 17: Guardians-Orioles Matchup Headlines Thursday's Top Betting Picks
MLB best bets and predictions for April 17's slate of games featuring three compelling matchups.

Baseball catcher awaits incoming pitch
Best Bet #1: Reds First 5 Innings Moneyline (-145) vs Mariners
- Mariners' Emerson Hancock struggles with 4.75 ERA, 1.34 WHIP in 2024
- Reds' Brady Singer shows promise with 3.18 ERA, 1.06 WHIP in 2025
- Mariners' offense underperforming at 3.88 runs per game
Best Bet #2: Guardians vs Orioles First 5 Innings Under 2.5 (+300)
- Orioles rank bottom half in wOBA (.307) and OBP (.300)
- Guardians' Tanner Bibee excelling with 10.1 scoreless innings in last two starts
- Orioles' Tomoyuki Sugano maintains solid 3.86 ERA in MLB debut season
Best Bet #3: Angels vs Rangers Over 9.5 Runs
- Rangers' Kumar Rocker struggling with 7.94 ERA, 1.94 WHIP
- Angels' Jack Kochanowicz showing regression with 5.74 ERA
- Angels rank 12th in runs per game (4.47)
- Both teams feature potent offenses and vulnerable pitching
Supporting Statistics:
- Guardians: 22nd in runs scored (3.88 RPG)
- Mariners: -6 run differential through 18 games
- Reds: +13 run differential through 18 games
- Orioles: 7-10 record, ranking 31st in OBP (.300)
These picks consider current team performance, pitcher matchups, and offensive capabilities, providing value opportunities for MLB bettors.
Related Articles
Guardians Face Blue Jays in Crucial Series Finale: Betting Preview and Odds August 14
