
McNeese vs Purdue Betting Odds: Boilermakers Favored by 7.5 Points in Second Round
The #12 McNeese Cowboys (28-6) will face the #4 Purdue Boilermakers (23-11) in the second round of the 2025 NCAA Tournament in Providence, following McNeese's stunning upset over Clemson.
Opening Betting Lines:
- Spread: Purdue -7.5
- Moneyline: Purdue -325, McNeese +260
- Total: 139.5 (Over/Under -110)

Basketball player celebrating victory pose
Recent Performance:
- McNeese defeated #5 Clemson 69-67 as 7.5-point underdogs
- Purdue handled High Point comfortably, maintaining a 75%+ win probability throughout
- Boilermakers are 14-1 against teams outside KenPom top 50
Key Stats:
- McNeese Leaders: Christian Shumate (13 pts, 11 reb), Brandon Murray (21 pts)
- Purdue Leaders: Trey Kauffman-Renn (21 pts, 8 reb vs High Point)
- Common Opponent: Alabama (McNeese lost 72-64 away, Purdue won 87-78 at home)

March Madness Selection Show
Notable Trends:
- McNeese outrebounded Clemson by 6 and recorded 6 blocks
- Purdue's Final Four odds now sit at +1000
- McNeese seeking first Sweet 16 appearance in school history
- Purdue aiming for second consecutive Sweet 16 berth
Betting splits and latest odds updates continue to develop as we approach game time.
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