March Madness First Round: Three Value Underdogs Worth Betting Early

March Madness First Round: Three Value Underdogs Worth Betting Early

By Marcus Sullivan

March 22, 2025 at 12:52 PM

March Madness 2025's first round presents three compelling underdog opportunities worth targeting early, based on opening lines and team matchups.

Man wearing blue shirt

Man wearing blue shirt

Drake (+5.5) vs Missouri

  • Drake's defense ranks 8th nationally in the last three games
  • Missouri's 5th-ranked offense faces strong defensive test
  • Line opened higher than expected at +5.5
  • Drake shows potential for straight-up win
  • Best odds: DraftKings (-102)

Yale (+7.5) vs Texas A&M

  • Yale shoots 37% from three-point range
  • Texas A&M struggles defending three-pointers
  • Slow-paced game favors Yale's style
  • Spread appears too wide given matchup
  • Best odds: FanDuel (-110)

Liberty (+5.5) vs Oregon

  • Nation's best effective field goal percentage
  • Unconventional offense difficult to prepare for
  • Slow pace will disrupt Oregon's 76 points per game average
  • Strong potential for straight-up victory
  • Best odds: DraftKings (-110)

All odds current as of March 16 at FanDuel & DraftKings.

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John Hyslop smiling at camera

John Hyslop smiling at camera

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